Co-expression network analysis of peripheral blood transcriptome identifies dysregulated protein processing in endoplasmic reticulum and immune response in recurrent MDD in older adults

LG Ciobanu; PS Sachdev; JN Trollor; S Reppermund; A Thalamuthu; KA Mather; S Cohen-Woods; D Stacey; C Toben; KO Schubert; BT Baune

Journal article

Co-expression network analysis of peripheral blood transcriptome identifies dysregulated protein processing in endoplasmic reticulum and immune response in recurrent MDD in older adults

LG Ciobanu, PS Sachdev, JN Trollor, S Reppermund, A Thalamuthu, KA Mather, S Cohen-Woods, D Stacey, C Toben, KO Schubert, BT Baune

Journal of Psychiatric Research | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2018

DOI: 10.1016/j.jpsychires.2018.09.017

Abstract

The molecular factors involved in the pathophysiology of major depressive disorder (MDD) remain poorly understood. One approach to examine the molecular basis of MDD is co-expression network analysis, which facilitates the examination of complex interactions between expression levels of individual genes and how they influence biological pathways affected in MDD. Here, we applied an unsupervised gene-network based approach to a prospective experimental design using microarray genome-wide gene expression from the peripheral whole blood of older adults. We utilised the Sydney Memory and Ageing Study (sMAS, N = 521) and the Older Australian Twins Study (OATS, N = 186) as discovery and replicatio..

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University of Melbourne Researchers

Bernhard Baune Author

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Grants

Awarded by Flinders University

Funding Acknowledgements

This work was supported by funding from the National Health and Medical Research Council (NHMRC; ID 1060524 to BTB, SCW, SR, JT) of Australia. The Sydney Memory and Ageing Study (sMAS) was supported by a National Health and Medical Research Council (NHMRC)/Australian Research Council Strategic Award (ID 401162), NHMRC Program Grants (ID 350833 and 568969) and a Project Grant (ID 1045325). The Older Australian Twins Study (OATS) was funded by an NHMRC/ARC Strategic Award Grant of the Ageing Well, Ageing Productively Program (ID 401162) and NHMRC Project Grant (ID 1045325 and 1085606). SCW is supported by the Matthew Flinders Fellowship, Flinders University, Australia.